HORDB

ID: hor002420
Uniprot ID: C7FDI3(75-84)
Protein name: Myosuppressin
Gene name: NA
Organism: Rhodnius prolixus (Triatomid bug)
Family: Myosuppressin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Rhodnius (genus), Triatominae (subfamily), Reduviidae (family), Reduvioidea (superfamily), Cimicomorpha (infraorder), Panheteroptera, Neoheteroptera, Euheteroptera, Heteroptera (suborder), Prosorrhyncha, Hemiptera (order), Paraneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: QDIDHVFMRF
Length: 10(75-84)
Propeptide: MILAWMCVTLLAGVLAAPGPDCSPSALQVQSSRVRNMCALYQISSALQAYLDEQNNYQTALRDTNIPYNIPEKRQDIDHVFMRFGRRR
Signal peptide: MILAWMCVTLLAGVLA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Inhibit spontaneous contraction of muscles
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: inhibition of contraction for hindgut : 1.3*10(-9)moll; for heart : 6*10(-9)moll
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002420_AF2.pdb

hor002420_ESM.pdb

Mass:	146821	Formula:	C59H86N16O16S
Absent amino acids:	ACEGKLNPSTWY	Common amino acids:	DF
pI:	5.41	Basic residues:	2
Polar residues:	0	Hydrophobic residues:	4
Hydrophobicity:	-20	Boman Index:	-2529
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	68
Instability Index:	2072	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 22623197
Title: An Unusual Myosuppressin From the Blood-Feeding Bug Rhodnius Prolixus